Solid - State Characterization of Bifonazole - Β - Cyclodextrin Binary Systems . Note I
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چکیده
Antimycotic bifonazole (BIF) is a very hydrophobic compound, which is a major drawback for obtaining topical pharmaceutical formulations with optimal bioavailabiliy and for the penetration into hydrophilic human nail matrices. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and β-cyclodextrin were prepared in two (BIF:β-CD) molar ratios by physical-mixture and kneaded method. Hot-stage microscopy (HSM), differential scanning calorimetry (DSC), X-ray diffractometry and Fourier-transformed infrared spectroscopy (FT-IR) were used to characterize solid state interactions between bifonazole and βcyclodextrin (β-CD) in their binary systems. The X-ray diffractograms, as well as the FTIR analysis suggest the formation of a new solid phase, indicating a molecular interaction between the components.The HSM analysis and the DSC analysis sustain the hypothesis of formation of partial inclusion complexes between BIF and β-CD.
منابع مشابه
Solid-state Characterization of Bifonazole – beta-cyclodextrin Binary Systems. II
CRISTINA TRANDAFIRESCU1, STEFANA AVRAM1*, CODRUTA SOICA1, ZOLTÁN AIGNER2, GYÉRESI ÁRPÁD3, MIHALY KATA2, CRISTINA DEHELEAN1, ZOLTÁN SZABADAI1, FLORIN BORCAN1 1Faculty of Pharmacy, Victor Babe’ University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041, Timisoara, Romania 2Faculty of Pharmacy, University of Szeged, 6th Eötvös Str., Szeged, Hungary 3Faculty of Pharmacy, University of Medic...
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